Skip to Main Content

Spotlight on... awareness weeks

Awareness weeks guide

World Kidney Day 2025

World Kidney Day

10 March 2025

World Kidney Day aims to raise awareness of the importance of our kidneys to our overall health and to reduce the frequency and impact of kidney disease and its associated health problems worldwide. World Kidney Day

UpToDate

Diabetic kidney disease

Diagnosis

Dialysis

General

Society Guideline links

Transplantation – Adults

Transplantation – Paediatrics

UpToDate Pathways

Cochrane Library

Online resources

Reports

Articles

Diagnosis and screening

Research

Risks

Treatment

E-books

E-journals

__________________________________________________________________________________

Articles

Diagnosis and screening

A comprehensive review of advanced biomarkers for Chronic Kidney Disease in older adults: Current insights and future directions
Chronic kidney disease (CKD) is a growing health concern, particularly in older adults, due to its high prevalence and association with increased morbidity and mortality. Early detection and effective management are crucial to slowing disease progression and reducing complications such as cardiovascular events and end-stage renal disease (ESRD). Traditional biomarkers, including serum creatinine and estimated glomerular filtration rate (eGFR), often have limitations in older populations, where age-related physiological changes can obscure early signs of kidney dysfunction. Advanced biomarkers offer a more precise and comprehensive understanding of kidney health, providing insights into pathological processes such as inflammation, fibrosis, oxidative stress, and tubular injury. These biomarkers have the potential to enhance early diagnosis, predict disease progression, and inform personalized treatment approaches, particularly in the elderly. This review explores the current landscape of advanced biomarkers for CKD in older adults, highlighting their clinical utility and limitations. Cureus 28 September 2025

Gaining insights into patients’ experiences of remote diagnostic screening for chronic kidney disease in patients with Diabetes
This study provides evidence for remote CKD screening and opens avenues for innovation. Most patients reported a positive experience, underscoring the potential of this approach to improve health outcomes, especially in higher-risk populations. Journal of patient experience 29 October 2024

Inside CKD: Cost-effectiveness of multinational screening for CKD
CKD screening may be cost-effective in general populations worldwide, including in populations aged over 45 years. This analysis corroborates global guideline recommendations for simultaneous estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio test (UACR), testing if considered in the context of local factors. KI Reports 24 January 2025

Risk factor-based screening for early detection of Chronic Kidney Disease in primary care settings: A systematic review
Risk factor-based screening effectively identifies a substantial proportion of people with undiagnosed CKD but there is still scope for improvement. The authors recommend future studies have robust designs and multidimensional interventions to establish the effectiveness of targeted CKD screening in primary care. Kidney medicine 12 February 2025

The potential use of targeted proteomics and metabolomics for the identification and monitoring of Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a prevalent microvascular complication of diabetes mellitus and is associated with a significantly worse prognosis compared to diabetic patients without kidney involvement, other microvascular complications, or non-diabetic chronic kidney disease, due to its higher risk of cardiovascular events, faster progression to end-stage kidney disease, and increased mortality. The aim of this review is to provide an overview of currently available data on targeted omics. Journal of personalized medicine 11 October 2024

________________________________________________________________________________

Research

Artificial Intelligence to predict chronic kidney disease progression to kidney failure: A narrative review
This narrative review highlights the most common and important variables used in machine learning models to predict progressive chronic kidney disease. Nephrology 6 January 2025

A systematic review for guidelines: Sports and high-grade kidney injuries in children with solitary kidneys
Summary:

  • To assess the risk of high-grade kidney injury in children participating in common sports.
  • The risk of kidney injury is generally low, with even lower risks for severe injury; most sports are safe, though motorised sports and equestrian activities carry higher risks.
  • Recommendations to exclude children with single kidneys should be carefully considered, personalised and based on shared decision-making that recognises baseline risks.

Acta Paediatrica 19 February 2025

Kidney biopsy-proven Diabetic and Non-Diabetic Kidney diseases and outcomes in patients with Type 2 Diabetes receiving Dialysis: The REIN Registry
The results of this study suggest that, for patients with diabetes treated with dialysis, the overall impact of diabetes on health outcomes is more crucial than the exact kidney disease. Understanding this could help improve treatment strategies for patients with diabetes undergoing dialysis. Kidney medicine 13 December 2024

Phosphorous metabolism and manipulation in chronic kidney disease
Phosphorus is a key element for the development of life. In humans, its levels are strictly regulated by feedback loops that are deranged in CKD due to the reduced nephron mass. Adaptive mechanisms are stimulated to enhance renal phosphate excretion. However, renal function deficit progression renders these mechanisms futile and exposes a subject with CKD to both phosphorus and adaptive mechanisms effectors toxicity. Nephrology 21 October 2024

Recovery of kidney function in acute kidney injury
This narrative review summarizes relevant studies on the definition and prediction of renal recovery. Journal of nephrology 1 March 2025

Systematic review of the effects of iron on cardiovascular, kidney, and safety outcomes in patients with CKD
Iron therapy may reduce the risk of heart failure and cardiovascular death in patients with CKD. Randomized trials evaluating the effects of iron on clinical outcomes are needed, especially in nondialysis patients with CKD with or without anemia. KI reports 29 January 2025

__________________________________________________________________________________

Risks

A narrative review of monogenic disorders causing nephrolithiasis and chronic kidney disease
The incidence and prevalence of genetic diseases associated with chronic kidney disease (CKD) have been increasing over the last decades. To identify the monogenic causes of kidney stone disorders linked to CKD, a comprehensive literature review was conducted to identify monogenic genes causing nephrolithiasis and CKD. Nephrology 5 November 2024

Association between remnant cholesterol and chronic kidney disease: Systematic review and meta-analysis
Remnant cholesterol (RC) is directly associated with higher risk for chronic kidney disease (CKD) . Beyond traditional lipid markers, greater emphasis should be placed on RC levels in individuals with or at risk for CKD. Diabetes, obesity and metabolism 14 February 2025

Obesity-related chronic kidney disease: From diagnosis to treatment
Obesity has emerged as a global epidemic with far-reaching health complications, including its role as an independent risk factor for chronic kidney disease (CKD). Increasing evidence suggests that obesity contributes to CKD through multiple mechanisms, including chronic inflammation, hemodynamic alterations, insulin resistance, and lipid accumulation. These processes can culminate in histopathological changes collectively referred to as obesity-related glomerulopathy (ORG). This review aims to provide a comprehensive overview of the current knowledge regarding the prevalence, clinical manifestations, and pathophysiology of ORG. Furthermore, the authors emphasize the importance of identifying key biomarkers that facilitate the early detection of ORG. Finally, we explore emerging therapeutic strategies that offer promise in mitigating this growing global health crisis. Diagnostics 14 January 2025

__________________________________________________________________________________

Treatment

Atrial Fibrillation in Advanced Chronic Kidney Disease: A survey of current management in Australia and New Zealand
This survey provides important contemporary insights into the management of AF in people with advanced CKD in Australia and New Zealand. There was inter- and intra-specialty heterogeneity in practice, highlighting the need for multidisciplinary care and research to improve cardiovascular outcomes in this population. Nephrology 10 February 2025

Current management of chronic kidney disease in type-2 diabetes—A tiered approach: An overview of the joint Association of British Clinical Diabetologists and UK Kidney Association (ABCD-UKKA) guidelines
What’s new?

  • Diabetes is the commonest cause of CKD and ESKD globally and these people have a very high risk of CVD and death.
  • Trial data confirm that the rate of progression to ESKD, CVD and mortality in people with with CKD due to type-2 diabetes can be can be effectively mitigated by established and newer interventions.
  • Recent studies demonstrate stark inadequacies and inequities in the management of diabetic CKD in the UK and elsewhere.
  • The updated ABCD-UKKA Guidlines incorporate all recent trial evidences and propose a tiered approach to implementation of the recommendations, to promote a holistic, individualised mutiple-risk factor intervention.

Diabetic medicine 17 October 2024

Efficacy of mineralocorticoid receptor antagonists on kidney and cardiovascular outcomes in patients with Chronic Kidney Disease: An umbrella review
Chronic kidney disease (CKD) can increase the risk of severe kidney problems and heart disease. A key factor in kidney decline and heart disease risk is the overactivation of mineralocorticoid receptors (MR). Medications called MR antagonists (MRAs) may lower heart disease risk. We performed a thorough review of all existing studies on both steroidal MRAs (sMRAs) and nonsteroidal MR antagonists (nsMRAs) to see how they might help reduce kidney and heart problems in different types of CKD. Our review found that sMRAs significantly lower the risk of death from all causes and heart issues in patients treated with dialysis, whereas nsMRAs reduce the chances of heart and kidney problems in patients not requiring dialysis. Both types of MRAs, however, do increase the risk of high potassium in patients requiring nondialysis. Kidney medicine 13 December 2024

Emerging antihypertensive therapies and cardiovascular, kidney and metabolic outcomes: A Mendelian randomisation study
This study highlights the potential of phosphodiesterase type 5 inhibitors (PDE5i), soluble guanylate cyclase stimulators (sGCs), endothelin receptor antagonists (ERA), and angiotensinogen inhibitors (AGTi) in reducing cardiovascular and renal risks. These findings underscore the necessity for targeted clinical trials to validate the efficacy and safety of these therapies. European heart journal 17 February 2025

Incremental Hemodialysis: Review of clinical trials focused on patients undergoing once-weekly Hemodialysis
1WHD has been shown to be safe and may result in improved clinical outcomes, particularly in appropriately selected patients. Large-scale randomized controlled trials should be carried out to confirm these potential advantages. However, the standard recruitment techniques applied tended to prevent suitably selected patients from transitioning into less frequent and potentially long-lasting 1WHD schedules. Nutrients 17 February 2025

Predicting major adverse cardiac events in diabetes and chronic kidney disease: a machine learning study from the Silesia Diabetes-Heart Project
Ten features-based ML models, especially the Light gradient boosting machine [LGBM] model, had acceptable performance in predicting cardiovascular events (CVEs) in persons with diabetes mellitus (DM) and chronic kidney disease (CKD). A decrease in eGFR, aging, and elevated inflammatory markers significantly enhanced the predictive capability of the model. Future external validation of our model is required prior to implementation in a clinical environment. Cardiovascular diabetology 15 February 2025

Reconsideration of the anemia management strategy for chronic kidney disease and dialysis patients
Anemia is common in patients with nondialysis-dependent (NDD) and dialysis-dependent (DD) chronic kidney disease (CKD). Although the capacity to produce substantial erythropoietin (EPO) remains high in these patients, insufficient EPO production is regarded as the main cause of renal anemia. Renal replacement therapy 1 March 2025

The impact of nurse-led care in chronic kidney disease management: a systematic review and meta-analysis
Nurse-led care provides notable benefits in managing certain aspects of CKD, including symptom control, sleep disturbances, energy levels, and overall health. However, its limited impact on kidney function and other clinical outcomes underscores the necessity for developing robust, standardized nurse-led care models and conducting long-term studies to evaluate their comprehensive efficacy. BMC nursing 18 February 2025

__________________________________________________________________________________

E-books

This is just a sample of the e-books the library subscribes to – you will need your library login

__________________________________________________________________________________

E-Journals

This is just a sample of the journals the library subscribes to – you will need your library login

__________________________________________________________________________________