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Consider… PATIENT FACTORS – age, medical conditions, risk of the interaction outcome to patient PHARMACOKINETICS – absorption, how the drug is metabolised by liver or excreted by kidneys, enzymes/kidneys transporters inhibited or induced PHARMACODYNAMICS – mechanism of action, receptors agonised/antagonised, similar side effects which may be additive TIME FACTORS – time for interaction to develop and resolve. Enzyme inhibition is generally rapid (2-3 days), whereas enzyme induction is generally slower (2 - 3 weeks) |
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